Thyroid hormone increases mannan-binding lectin levels

CLINICAL STUDY Thyroid hormone increases mannan-binding lectin levels

Background: Recent studies have indicated the existence of causal links between the endocrine and immune systems and cardiovascular disease. Mannan-binding lectin (MBL), a protein of the innate immune system, may constitute a connection between these fields. Methods: To test whether thyroid hormone regulates MBL levels, we studied eight patients with Graves’ hyperthyroidism before and after met...

Association between Low Levels of Mannan-Binding Lectin and Markers of Autoimmune Thyroid Disease in Pregnancy

Functional deficiency of mannan-binding lectin (MBL) has been associated with adverse pregnancy outcome. Adverse events during pregnancy have also been described in women with autoimmune thyroid diseases (AITD), and thyroid hormones have been shown to influence serum levels of MBL. Therefore, the aim of this study was to analyse the impact of MBL-deficiency on the outcome of pregnancy in relati...

Mannan-binding lectin (MBL) serum levels and post-operative infections.

Mannan-binding lectin (MBL) is a central component of the innate immune system. Here we investigated the role of MBL in surgical patients during the peri-operative phase. Basal and post-operative (days 1-3 post-surgery) serum samples were obtained prospectively from 156 patients undergoing major elective gastrointestinal surgery for malignant disease. In contrast to procalcitonin (a typical acu...

Polymorphisms in Mannan-Binding Lectin

Introduction to mannan-binding lectin.

Mannan-binding lectin (MBL) was first discovered as a plasma opsonin for baker's yeast and was independently characterized biochemically. It belongs to the small subfamily of collectins: C-type lectins possessing a collagen-like domain. MBL is synthesized by the liver and secreted into the bloodstream. It is believed to be an important component of innate immunity, acting as an ante-antibody an...